The brown recluse spider bite usually causes some pain or burning in the first 10 minutes, accompanied by itching. The wound takes on a bull's-eye appearance, with a center blister surrounded by an angry-looking red ring and then a blanched (white) ring. The blister breaks open, leaving an ulcer that scabs over. The ulcer can enlarge and involve underlying skin and muscle tissue. Pain may be severe. A generalized red, itchy rash usually appears in the first 24-48 hours. Other symptoms include fever, chills, nausea, vomiting, muscle aches and hemolytic anemia (a condition where the red blood cells are destroyed).